MISSENSE MUTATION AND NON SENCE MUTATION

MISSENSE MUTATION AND NON SENCE MUTATION;

MISSENSE MUTATION
         
 In genetic,a missense mutation is a point mutation in which a single nucleotide change result in a codon that codes for a different amino acid . It is a type of non synonymous substitution.

One of nucleotide (adenine ) is replaced by another nucleotide ( cytosine ) in the DNA sequence.This result in an incorrect amino acid being Incorporated into the protein sequence.  

NON SENSE MUTATION

   In genetics,a nonsense mutation is a point mutation in a sequence of DNA that results in a premature stop codon, or a nonsense codon in the transcribed mRNA, and in a truncated, incomplete, and usually non functional protein product. It differs from a missense mutation, which is a point mutation where a single nucleotide is changed to cause substitution of a different amino acid. Some genetic disorders, such as thalassemia and DNA results from nonsense mutations.